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MYP_038939
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Basic Information
T20 [H6R; S7E; L8,26I; I9M; E10N; E11K; Q13W; N14G; E17R; K18R; Q21G; E22T; L24A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
36 amino acids
C201H300N56O56S
Standard
Sequence
YTSLIREIMNKSWGQQRRNEGTLAEIDKWASLWNWF
Physicochemical Analysis
4428.94 Da
8.50
0.77
0.55
0.0213
-0.81
0.57
-0.10
44.68
70.56
0.1667
23490.00
23490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1868.75
-15.20
67.0
58.0
146.0
314.0
10.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0256959 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 92HT021:inhibition of pseudovirus infection in U87 cells
0.24 μg/mL
IC50
PaperPubMed PMID: 31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0308640 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 PsV
PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0326987 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 IAVI C22 | U87 cells
1.11 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperOptimization of peptidic HIV-1 fusion inhibitor T20 by phage display. | Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. | Protein Sci. 2019 Aug;28(8):1501-1512. | DOI:10.1002/pro.3669 | PMID:31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0356969 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 JRCSF-GIA:inhibition of pseudovirus infection in U87 cells
10.2 μg/mL
IC50
PaperPubMed PMID: 31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
RECORD: Rec_0361448 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 92BR020 | U87 cells
0.53 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperOptimization of peptidic HIV-1 fusion inhibitor T20 by phage display. | Chen G, Cook JD, Ye W, Lee JE, Sidhu SS. | Protein Sci. 2019 Aug;28(8):1501-1512. | DOI:10.1002/pro.3669 | PMID:31228294 PMID31228294 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31228294/
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