Peptide Database

Peptide NameProthyroliberin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length177 amino acids

Chemical FormulaC876H1405N281O281S7

DescriptionStandard

        QDGPAEEELFQRAEDLLLRSILTQMEEQNSENDQPEWMEKRQHPGKRQHPGKREEDLEPEVEMERWRRQHPGKRAPLDLGMLEDPTALSELSKRQHPGKRYLMLLHKRQHPGRRELQEADGDSAELEKRQHPGKRRCEGWADAGCGLLELLDTSGAPEKRQHPGRRAELEDELPGLE
    

Molecular Weight20593.70 Da

Isoelectric Point (pI)5.48

Net Charge (pH 7.0)-8.48

Net Charge (pH 7.4) -9.19

Charge Density (pH 7.0) -0.0479

GRAVY Index-1.42

Hydrophobic Moment 0.70

Boman Index-0.36

Instability Index81.38

Aliphatic Index 60.17

Aromaticity 0.0282

Extinction Coeff. Reduced 17990.00

Extinction Coeff. Oxidized 18115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 9140.22

LogP -101.66

H-bond Donors 311.0

H-bond Acceptors 287.0

Rotatable Bonds 706.0

Heavy Atoms 1445.0

Ring Count 30.0

Amide Bonds 191.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0190013 VERIFIED: NO

Provenance & Taxonomy

OrganismDanio rerio [Animal]

FamilyTRH

Tax ID7955

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsGln42 Pyroglutamylation; Pro44 Amidation; Gln48 Pyroglutamylation; Pro50 Amidation; Gln69 Pyroglutamylation; Pro71 Amidation; Gln95 Pyroglutamylation; Pro97 Amidation; Gln109 Pyroglutamylation; Pro111 Amidation; Gln130 Pyroglutamylation; Pro132 Amidation; Gln161 Pyroglutamylation; Pro163 Amidation

Bio-Activity Profile

Function

Hormone Neuropeptide