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MYP_038811
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Basic Information
Aurein 2.2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
72 amino acids
C355H578N96O115S2
Standard
Sequence
MAFLKKSLFLVLFLGLVSLSICEKEKRQNEEDEDENEAANHEEGSEEKRGLFDIVKKVVGALGSLGKRNDLE
Physicochemical Analysis
8095.09 Da
4.90
-5.39
-5.71
-0.0748
-0.46
0.79
-0.09
44.22
96.11
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3465.36
-31.99
118.0
113.0
292.0
568.0
5.0
76.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006016 VERIFIED: NO
Provenance & Taxonomy
Litoria aurea [Animal]
Aurein
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15721491 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15721491/
RECORD: Rec_0146775 VERIFIED: YES
Provenance & Taxonomy
Ranoidea aurea [Animal]
Frog skin active peptide (FSAP); Aurein subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Non-hemolytic
No Target Organism Found
PMID15721491;10951191;11784303;17259271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15721491/
RECORD: Rec_0158416 VERIFIED: YES
Provenance & Taxonomy
Litoria aurea [Animal]
Aurein
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0178468 VERIFIED: YES
Provenance & Taxonomy
Litoria aurea [Animal]
Aurein
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0370904 VERIFIED: YES
Provenance & Taxonomy
Litoria aurea [Animal]
Aurein
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/