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MYP_038767
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Basic Information
Omiganan
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Wound healing
Standard
12 amino acids
C90H126N26O13
Standard
Sequence
ILRWPWWPWRRK
Physicochemical Analysis
1780.13 Da
12.00
3.76
3.55
0.3133
-1.32
0.63
-0.26
131.93
65.00
0.3333
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
640.72
1.65
25.0
17.0
49.0
129.0
10.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0279371 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Indolicidin analogue
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial
Enterococcus faecium (including VSE/VRE strains)
8-16 μg/mL
MIC
PaperAntimicrobial and antifungal activities of a novel cationic antimicrobial peptide, omiganan, in experimental skin colonisation models PMID19524411 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19524411/
RECORD: Rec_0295814 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Helical peptide with a predominance of one or more amino acids tryptophane-rich
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
U-937
0.5 μg/mL
Cytotoxicity assay
PMID14508884;21403917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14508884/
RECORD: Rec_0301313 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0361538 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Indolicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Wound healing
Staphylococcus aureus ATCC 25923 or 9144
16 μg/mL
MIC
PaperRetro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides.
RECORD: Rec_0364439 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]; Bos taurus [Animal]
Designed peptide
32630; 9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID21403917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21403917/
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