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MYP_038767
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Basic Information
Omiganan
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Wound healing/Regeneration ▸ Wound healing
Standard
12 amino acids
C90H126N26O13
Standard
Sequence
ILRWPWWPWRRK
Physicochemical Analysis
1780.13 Da
12.00
3.76
3.55
0.3133
-1.32
0.63
-0.26
131.93
65.00
0.3333
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
640.72
1.65
25.0
17.0
49.0
129.0
10.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060938 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Indolicidin analogue
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial
Escherichia coli
8-16 μg/mL
MIC
PaperAntimicrobial and antifungal activities of a novel cationic antimicrobial peptide, omiganan, in experimental skin colonisation models PMID19524411 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19524411/
RECORD: Rec_0061576 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
8 μg/mL
MIC
PMID28453851 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28453851/
RECORD: Rec_0070235 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Indolicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Wound healing
Candida albicans ATCC 10231
128 μg/mL
MIC
PaperRetro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides.
RECORD: Rec_0126145 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Indolicidin analogue
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial
Methicillin-susceptible Staphylococcus epidermidis (MSSE)
4 μg/mL
MIC
PaperAntimicrobial and antifungal activities of a novel cationic antimicrobial peptide, omiganan, in experimental skin colonisation models PMID19524411 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19524411/
RECORD: Rec_0139838 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Bovine neutrophils
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
U-937
80-85 μg/mL
IC50
PMID21403917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21403917/
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