Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length497 amino acids

Chemical FormulaC2456H3914N662O687S12

DescriptionStandard

        MVVPIRTWAALVALVGVAGVWAANPGFVVRISQKGLDYARQESIVALEKELLKINLPDFSGSFKIKHFGKGHYDFNSLEINNFRLPTSQISLLPGQGLRVAMSNAFIQVSGHWKARKNFIKLNGSFNLKVEGLSIMTDLHLGSDQNGRPTVSASACNSQISNVKVHISGRLSWILNLFHKKIESRFRKSMEGKICEKVMSAARSKLQPYLQTLPVTAKIDKVAGIDYALVHPPKSSASTLDVGLKGEFFNLNQRSPPPFAPPELNFPPASDRMAYFGVSDYFFNTAFSVYHKAGALRLSVSDDMIPKESKIRLNTASFGGLIPQLAKTYPNVAMKLVVSTAAAPSLSIRPGSLNLGPDLDVEALALPPNASEVPLFLLGLSTNASVEVGVRGANIFGSTKLGRLNLELKQSSVGPFSVTLLEAVMNFYVSQVLLPKANERLEKGFPLPLFQKLQLSNLVLQPLQVRRTPSPLPTVPQPPPPTPRDPPRCPGALEDSV
    

Molecular Weight54092.15 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)19.20

Net Charge (pH 7.4) 18.43

Charge Density (pH 7.0) 0.0386

GRAVY Index-0.01

Hydrophobic Moment 0.71

Boman Index0.09

Instability Index39.27

Aliphatic Index 97.10

Aromaticity 0.0785

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108425 VERIFIED: NO

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria