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MYP_038602
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Basic Information
Dhvar4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C90H150N24O17
Standard
Sequence
KRLFKKLLFSLRKY
Physicochemical Analysis
1840.30 Da
11.22
5.76
5.54
0.4111
-0.42
0.72
-0.31
29.53
111.43
0.2143
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
709.96
-1.65
27.0
23.0
66.0
131.0
3.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0213222 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antifungal
Candida albicans ATCC SC5314
1 nmol/cm2
Total countable CFUs
RECORD: Rec_0222563 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Histatin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
amphotericin B-resistant Candida albicans, Cryptococcus neoformans 316, C. krusei 355, C. parapsilosis 356, and a fluconazole-resistant C. glabrata B57149 isolate
0.7-2.4 μM
IC50
PaperAmphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides
RECORD: Rec_0243184 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Histatin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
16 μM
MIC
PaperAmphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides
RECORD: Rec_0269094 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
0.9 μM
LC50
PMID16940535;10338115;10518718;31207076 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16940535/
RECORD: Rec_0289732 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Streptococcus mutans UA159
6.8 μM
MIC
PMID31207076 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31207076/
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