Peptide Database

Peptide NameHellethionin-D

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC198H320N64O66S8

DescriptionStandard

        KSCCRNTLARNCYNACRFTGGSQPTCGILCDCIHVTTTTCPSSHPS
    

Molecular Weight4909.57 Da

Isoelectric Point (pI)8.53

Net Charge (pH 7.0)2.85

Net Charge (pH 7.4) 2.43

Charge Density (pH 7.0) 0.0621

GRAVY Index-0.22

Hydrophobic Moment 0.66

Boman Index-0.05

Instability Index62.01

Aliphatic Index 44.57

Aromaticity 0.0435

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2088.18

LogP -33.02

H-bond Donors 82.0

H-bond Acceptors 79.0

Rotatable Bonds 152.0

Heavy Atoms 336.0

Ring Count 7.0

Amide Bonds 49.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0316309 VERIFIED: YES

Provenance & Taxonomy

OrganismHelleborus purpurascens [Plant]

FamilyThionin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Toxin

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