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MYP_038573
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Basic Information
Hellethionin-D
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
46 amino acids
C198H320N64O66S8
Standard
Sequence
KSCCRNTLARNCYNACRFTGGSQPTCGILCDCIHVTTTTCPSSHPS
Physicochemical Analysis
4909.57 Da
8.53
2.85
2.43
0.0621
-0.22
0.66
-0.05
62.01
44.57
0.0435
1490.00
1990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2088.18
-33.02
82.0
79.0
152.0
336.0
7.0
49.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0069645 VERIFIED: NO
Provenance & Taxonomy
Helleborus purpurascens [Plant]
Thionin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ6422
RECORD: Rec_0090887 VERIFIED: YES
Provenance & Taxonomy
Helleborus purpurascens [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 12600207 PMID12600207 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12600207/
RECORD: Rec_0160536 VERIFIED: NO
Provenance & Taxonomy
Helleborus purpurascens [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-40; 4-32; 12-30; 16-26
Bio-Activity Profile
Toxin
It seems to exert
RECORD: Rec_0216512 VERIFIED: YES
Provenance & Taxonomy
Helleborus purpurascens [Plant]
plant thionin (TC 1.C.44) family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-40; 4-32; 12-30; 16-26
Bio-Activity Profile
Toxin Venom plant thionin (TC 1.C.44) family Host defense
PaperPDB 3SZS structural record; X-ray; 1.95 A; chain A/B/C/D/E/F/G; residues 1-46
RECORD: Rec_0280656 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 41.3%, E 4.3%, T 23.9%, C 30.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
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