Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2351H3720N606O661S16

DescriptionStandard

        MAWRLTVAFMVAACVAHAGATNPGFVVRVTSKGLDYARQVGVTILQKELSTIKLPDFSGTFHIKHLGKGHYSFHDLLIRQFLLPSSQIVPVPNASLKLSISNGFIQLDGQWQAKKSFIKDHGSFDLKVEGLSVTVSLALGSDGSGRPTISTTSCSNHIANVRVHISGKASWLLDLFHKKIEAEFRNVMEGKICSIVSESIKTKLQPSLQTLPVTAKIDHIAGIDYSLVGPPTATAESIDVNLKGEFFDLAHRSPVPFSPPAVAFPVDHNLMLYCGVSDYFFNTASFVYQAAGALIFNVTDDMIPKDFQMRLNTSTFGTLIPQVQKMFPNMLMKLMMSSPSAPFLKITPGNLTVTPTLDIQAFALLPNSSLAPLFLLSVTTGVTAKIAVNSTRIIGNLALSRLLMTLKHSDVGTFSVAVLDVAVNYYVSHILLPEINDKLGRGYPLPVLDHLVLTDLILKPQQDFLQLGANVNYG
    

Molecular Weight51563.39 Da

Isoelectric Point (pI)8.85

Net Charge (pH 7.0)5.78

Net Charge (pH 7.4) 4.67

Charge Density (pH 7.0) 0.0122

GRAVY Index0.26

Hydrophobic Moment 0.65

Boman Index0.19

Instability Index35.55

Aliphatic Index 105.08

Aromaticity 0.0844

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423392 VERIFIED: NO

Provenance & Taxonomy

OrganismGeotrypetes seraphini (Gaboon caecilian) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria