Peptide Database

Peptide NameSLAY-screened peptide P2251

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC103H152N26O34

DescriptionStandard

        SYHISLASISTSSYGQYPHVT
    

Molecular Weight2298.46 Da

Isoelectric Point (pI)6.66

Net Charge (pH 7.0)-0.37

Net Charge (pH 7.4) -0.68

Charge Density (pH 7.0) -0.0175

GRAVY Index-0.15

Hydrophobic Moment 0.11

Boman Index0.19

Instability Index39.70

Aliphatic Index 74.29

Aromaticity 0.1429

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 959.51

LogP -12.20

H-bond Donors 35.0

H-bond Acceptors 36.0

Rotatable Bonds 68.0

Heavy Atoms 163.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0043119 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/