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MYP_038393
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Basic Information
Anticancerous peptide 1 (Cr-ACP1; Plants)
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
9 amino acids
C50H71N11O14
Standard
Sequence
AWKLFDDGV
Physicochemical Analysis
1050.16 Da
4.21
-1.20
-1.39
-0.1337
0.04
0.62
0.22
13.17
86.67
0.2222
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
412.53
-1.32
14.0
13.0
32.0
75.0
3.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063369 VERIFIED: YES
Provenance & Taxonomy
Cycas revoluta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Hemolytic
Hemocompatibility study revealed the effectiveness of both the peptides where it showed no significant lysis of normal RBC cells compare to positive control (Triton X-100)
PMID21882228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21882228/
RECORD: Rec_0084996 VERIFIED: YES
Provenance & Taxonomy
Cycas revoluta [Plant]
3396
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer Pro-apoptotic Antibacterial
PaperIdentification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties PMID21882228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21882228/
RECORD: Rec_0087996 VERIFIED: YES
Provenance & Taxonomy
Cycas revoluta [Plant]
Anticancerous peptide 1
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-negative
Pseudomonas aeruginosa
30 μM
MIC
PMID21882228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21882228/
RECORD: Rec_0098992 VERIFIED: YES
Provenance & Taxonomy
Cycas revoluta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Cytotoxic
mM in HCT15 (human colon carcinoma cells HCT15)
PMID21882228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21882228/
RECORD: Rec_0107684 VERIFIED: YES
Provenance & Taxonomy
Cycas revoluta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Staphylococcus epidermidis
60 μM
MIC
PMID21882228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21882228/
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