Peptide Database

Peptide NameSLAY-screened peptide P4532

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC123H168N26O24

DescriptionStandard

        TLFTYLAVFFHLILAGHFFH
    

Molecular Weight2394.81 Da

Isoelectric Point (pI)6.73

Net Charge (pH 7.0)-0.34

Net Charge (pH 7.4) -0.68

Charge Density (pH 7.0) -0.0171

GRAVY Index1.44

Hydrophobic Moment 0.29

Boman Index0.67

Instability Index13.95

Aliphatic Index 122.00

Aromaticity 0.3000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 762.95

LogP 0.99

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 70.0

Heavy Atoms 173.0

Ring Count 9.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0406183 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/