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MYP_038194
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Basic Information
Defensin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
38 amino acids
C181H279N65O48S6
Standard
Sequence
GFGCPLNQGACHRHCRSIRRRGGYCAGFFKQTCTCYRN
Physicochemical Analysis
4325.95 Da
9.69
6.87
6.48
0.1808
-0.65
0.82
-0.22
85.93
25.79
0.1316
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1859.52
-24.36
74.0
63.0
139.0
300.0
8.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020847 VERIFIED: NO
Provenance & Taxonomy
Leiurus quinquestriatus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
RECORD: Rec_0065344 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 26.3%, E 15.8%, T 36.8%, C 21.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0152422 VERIFIED: NO
Provenance & Taxonomy
Leiurus quinquestriatus hebraeus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Paper4 kDa defensin Evidence URLhttps://www.uniprot.org/uniprotkb/P41965/entry
RECORD: Rec_0172706 VERIFIED: NO
Provenance & Taxonomy
Leiurus hebraeus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Anti-MRSA Anti-Gram-negative Anti-Gram-positive Hemolytic Non-ribosomal
Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus
Qualitative functional evidence
PMID8333834 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8333834/; https://www.uniprot.org/uniprotkb/P41965/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0174947 VERIFIED: YES
Provenance & Taxonomy
Leiurus quinquestriatus hebraeus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals that this sequence is similar (97.37%) to scorpion defensin C=R=G: 16%. GRAVY: -0.65; mol Wt: 4326.013; mol formula: C181H281N63O48S6; mol ex coeff: 3355. Chemical modification: 3 disulfide bonds
Bio-Activity Profile
Antimicrobial
Staphylococcus epidermidis
0.33-0.42 μM
MIC
PaperNovel structural determinants and bacterial death-related regulatory effects of the scorpion defensin BmKDfsin4 against gram-positive bacteria PMID39488304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/39488304/
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