Peptide Database

Peptide NameSLAY-screened peptide P5021

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC78H133N27O25S

DescriptionStandard

        GRRIQPHSLSPCTATASV
    

Molecular Weight1881.12 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.57

Charge Density (pH 7.0) 0.1021

GRAVY Index-0.25

Hydrophobic Moment 0.38

Boman Index-0.07

Instability Index90.30

Aliphatic Index 70.56

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 837.16

LogP -12.50

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 57.0

Heavy Atoms 131.0

Ring Count 3.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0396576 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/