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MYP_038032
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Basic Information
Alo-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
34 amino acids
C147H221N49O48S6
Standard
Sequence
CIANRNGCQPDGSQGNCCSGYCHKEPGWVAGYCR
Physicochemical Analysis
3635.02 Da
7.78
0.79
0.44
0.0232
-0.71
0.28
-0.09
30.82
25.88
0.0882
8480.00
8855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1571.30
-22.76
59.0
56.0
113.0
250.0
7.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023306 VERIFIED: YES
Provenance & Taxonomy
Anoplophora glabripennis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0043777 VERIFIED: YES
Provenance & Taxonomy
Acrocinus longimanus and [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
also isolated from Monochamus alternatus (Han et al., 2023). found in multiple species. Chemical modification: C1-C4, C2-C5, and C3-C6.three disulfide bonds:
Bio-Activity Profile
Antifungal
B. thuringiensis
36.29 μg/mL
MIC
PaperSolution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus
RECORD: Rec_0151260 VERIFIED: YES
Provenance & Taxonomy
Acrocinus longimanus and [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
also isolated from Monochamus alternatus (Han et al., 2023). found in multiple species. Chemical modification: C1-C4, C2-C5, and C3-C6.three disulfide bonds:
Bio-Activity Profile
Antifungal
Escherichia coli
36.29 μg/mL
MIC
PaperSolution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus
RECORD: Rec_0158142 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antifungal
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0283590 VERIFIED: YES
Provenance & Taxonomy
Acrocinus longimanus and [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
also isolated from Monochamus alternatus (Han et al., 2023). found in multiple species. Chemical modification: C1-C4, C2-C5, and C3-C6.three disulfide bonds:
Bio-Activity Profile
Antifungal Toxicity
ed pine wood nematodes nematocidal
362 μg/mL
LC50
PaperSolution structure of Alo-3: a new knottin-type antifungal peptide from the insect Acrocinus longimanus
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