Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2312H3630N618O638S9

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGIAILEKELAQLTLPDISGDFRFLRVGKVHYELSRLRLRNFHLPFSRISPVPNVGLQVSISNAFAELDGDWRVKMLFIRDHGSFDLKVENVYIKINLRLGSDAAGKPTISTSECSTRISKVRVLFSSKFGWLYNLFHSAIESKFKKILESKVCDSVAKSVHSELQTYIQTLPVTAKIDARTGIDYSFVAPPVATAQSLDTGLKGEFYSLAHRSTAPFSPLPLSLPLDHDRMVYFGASSYFFNTAGFAYHSSGALVFEITDAMIPKDVDFHLNTSIFSAFIPQLEQMYPNMPMKLRLSTLTAPFLNIGPGGISLKPVVDAQAYAILPNSTLAPLFVLSLVRNVSAVIDVRSGHIVGSLNVGRYGGERLLLGRGRLGVRLLQSIMNIFASNILLPRLNARLDEGFPLPLPDRIQLFNTSVRFHQNFLLLGADVHFQPK
    

Molecular Weight50579.90 Da

Isoelectric Point (pI)9.48

Net Charge (pH 7.0)10.54

Net Charge (pH 7.4) 9.58

Charge Density (pH 7.0) 0.0231

GRAVY Index0.11

Hydrophobic Moment 0.77

Boman Index0.12

Instability Index38.43

Aliphatic Index 103.27

Aromaticity 0.1009

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0132509 VERIFIED: NO

Provenance & Taxonomy

OrganismMionectes macconnelli [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria