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MYP_037975
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Basic Information
Polybia-MPI [L14L-S]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IDWKKLLDAAKQIX
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023159 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 14
Bio-Activity Profile
Cytotoxic
Mouse fibroblasts NIH 3T3
>60 μM
Cytotoxicity
PMID20600424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20600424/
RECORD: Rec_0112032 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 14
Bio-Activity Profile
Anticancer Cytotoxic
Human endometrial adenocarcinoma EJ
21.6
IC50
PMID20600424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20600424/
RECORD: Rec_0117604 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Leu-S
Bio-Activity Profile
Antimicrobial Anticancer
EJ
21.6±1.2 μM
IC50
PaperPubMed PMID: 20600424 PMID20600424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20600424/
RECORD: Rec_0127035 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 14
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
32 μM
MIC
PMID20600424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20600424/
RECORD: Rec_0193811 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 14
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis ATCC 12228
16 μM
MIC
PMID20600424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20600424/
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