Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length522 amino acids

Chemical FormulaC2654H4106N664O765S20

DescriptionStandard

        MDGRMEGWMDGWMDGIHMKMAQVLWGYFLLWNFYISSTQTIYPGIKARATQRALDYGVQAGIEMIEQMAKERNIPDLKGSESLEFLKIDYVNYNFTNIKIHALSFPNTSLAFVPGVGIKALTNHGMANISTNWEVKSPLFQDTGGADLFLSGVYFTGLLILTRNDFGHPTLQLQDCYSQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITGEVEALNANLSMLEVLTKMDNYTLLDFSLLNAPEITENNIDLDLKGVFYPLENLADPPFPSVPFVLPERSDSMLYIGISEYFFKSASFAYFTAGAFNVTLSTKEISSHLVQNSQGVGNVLSRIAEIYILSQPFMIRIMATAPPVINLLPGNFTLDIPASIVILTQPENSTVETIVSMDFVASTSVGLVILGQRLICSLSLNRFRLTLPKSSRSNIEVLRFENILSFIIHFGILPLANAKLQQGFPLPNPHKISFVNSDIEVLEHFLLISTDLRYETSLKQQPSFHGWEGLNLISGQWSGNSAP
    

Molecular Weight58196.28 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-16.50

Net Charge (pH 7.4) -17.43

Charge Density (pH 7.0) -0.0316

GRAVY Index0.13

Hydrophobic Moment 0.67

Boman Index0.18

Instability Index40.93

Aliphatic Index 101.61

Aromaticity 0.1054

Extinction Coeff. Reduced 62340.00

Extinction Coeff. Oxidized 62465.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0186650 VERIFIED: NO

Provenance & Taxonomy

OrganismRousettus aegyptiacus (Egyptian rousette) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria