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MYP_037913
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Basic Information
Circulin B
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Standard
31 amino acids
C138H224N36O42S6
Standard
Sequence
GTLPCGESCVWIPCISSVVGCSCKSKVCYKN
Physicochemical Analysis
3251.86 Da
8.33
1.70
1.40
0.0548
0.47
0.34
0.18
30.47
75.16
0.0645
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1234.59
-14.67
49.0
50.0
102.0
222.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005699 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0012333 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 38.7%, T 35.5%, C 25.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0161338 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant],Viola adunca [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic
Trichostrongylus colubriformis
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 10600380 PMID10600380 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600380/
RECORD: Rec_0235861 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant],Viola adunca [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic
Haemonchus contortus
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 10600380 PMID10600380 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600380/