Peptide Database

Peptide NameSLAY-screened peptide P2511

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H161N35O28

DescriptionStandard

        NIDTWPSHFRLHTRFGRATP
    

Molecular Weight2409.66 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.0968

GRAVY Index-0.93

Hydrophobic Moment 0.72

Boman Index-0.17

Instability Index17.11

Aliphatic Index 44.00

Aromaticity 0.1500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1018.80

LogP -10.22

H-bond Donors 37.0

H-bond Acceptors 32.0

Rotatable Bonds 71.0

Heavy Atoms 172.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0176495 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/