Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length522 amino acids

Chemical FormulaC2659H4141N657O761S21

DescriptionStandard

        MITGWMDGWMEQVLEMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGMEMIEQMVKKRNIPDLKGSESLEFLKIDYVNYNFKNIKINAFSLPNTSLAFVPGVGIRALINHGTANISTDWEIKSPLFQDTGGADLFLSGVYFTGIVVLAWNDFGHPILKLQNCCARVSHSDVSFSGELSVLYNSFSEPMEKPILKNLNKMLCPIITSEVEALNANLSMLKALRKIDNYTLLDYSLISSPEITENYVDLNLKGVFYPLENLTDTPFSSVPFVLPEHSDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTKEIFNHLIRNSQGLGSMLSQIAELYILSQPFMVKVLATEPPVVNLLPGNFTLDIPASFVIFTQSKNSTAKTIVSMDFVASTNVALAILGQRLICSLSLKSFYLSLPESSRSNTEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPQNISLVNSDIEVLEGFVLISTDLKYKTSLKQQPSFHGWEALNLISGQWRGKPAP
    

Molecular Weight58161.63 Da

Isoelectric Point (pI)5.74

Net Charge (pH 7.0)-5.90

Net Charge (pH 7.4) -6.68

Charge Density (pH 7.0) -0.0113

GRAVY Index0.16

Hydrophobic Moment 0.69

Boman Index0.18

Instability Index40.19

Aliphatic Index 102.72

Aromaticity 0.1073

Extinction Coeff. Reduced 70820.00

Extinction Coeff. Oxidized 71195.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0024619 VERIFIED: NO

Provenance & Taxonomy

OrganismBalaenoptera musculus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria