Peptide Database

Peptide NameSLAY-screened peptide P4469

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC67H100N22O17

DescriptionStandard

        VPHHSYFSSRRI
    

Molecular Weight1485.65 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)1.91

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.1589

GRAVY Index-0.77

Hydrophobic Moment 0.31

Boman Index-0.20

Instability Index105.05

Aliphatic Index 56.67

Aromaticity 0.1667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 636.71

LogP -6.43

H-bond Donors 24.0

H-bond Acceptors 21.0

Rotatable Bonds 44.0

Heavy Atoms 106.0

Ring Count 5.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108660 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/