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MYP_037772
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Basic Information
Temporin L[Pro3,DLeu9,Lys10](TL8)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C87H129N19O15
Standard
Sequence
FVPWFSKFLKRIL
Physicochemical Analysis
1681.07 Da
11.17
2.76
2.55
0.2122
0.70
0.74
0.26
55.19
112.31
0.3077
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
553.69
1.48
20.0
18.0
52.0
121.0
6.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0246565 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida crusei ATCC 6258
1.56 μM
MIC
PaperGlycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities. Eur J Med Chem. 2017 Oct 20;139:750-761. doi: 10.1016/j.ejmech.2017.08.040. PMID: 28863356. PMID28863356 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28863356/
RECORD: Rec_0249856 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HSV-1:inhibition of HSV-1 replication in Vero cells
2.49 μM
IC50
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0270897 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Hemolytic
Human RBC
50 μM
Hemolysis
PMID28863356;35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28863356/
RECORD: Rec_0276976 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Acinetobacter baumannii ATCC 19606
3.125 μM
MIC
PaperGlycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities. Eur J Med Chem. 2017 Oct 20;139:750-761. doi: 10.1016/j.ejmech.2017.08.040. PMID: 28863356. PMID28863356 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28863356/
RECORD: Rec_0280091 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HCoV-OC43 Replication inhibition
HCoV-OC43 | Vero cells
8.29 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
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