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MYP_037691
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Basic Information
Bombolitin I (insects, arthropods, invertebrates, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C85H154N22O20S
Standard
Sequence
IKITTMLAKLGKVLAHV
Physicochemical Analysis
1836.33 Da
10.30
2.84
2.59
0.1673
1.04
0.60
0.32
-20.55
160.59
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
676.12
-2.76
24.0
25.0
64.0
128.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033911 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic Hemolytic
guinea pig erythrocytes
PaperPubMed PMID: 2578459 PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0040312 VERIFIED: YES
Provenance & Taxonomy
American common bumblebee [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperBombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus.
RECORD: Rec_0050295 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Hemolytic activity
4.0±0.05 μg/mL
Hemolysis
PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0079161 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic
PaperPubMed PMID: 2578459 PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0088471 VERIFIED: NO
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone
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