Peptide Database

Peptide NameSLAY-screened peptide P2554

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC29H42N10O8

DescriptionStandard

        THPPAH
    

Molecular Weight658.71 Da

Isoelectric Point (pI)6.61

Net Charge (pH 7.0)-0.43

Net Charge (pH 7.4) -0.72

Charge Density (pH 7.0) -0.0712

GRAVY Index-1.42

Hydrophobic Moment 0.14

Boman Index0.00

Instability Index53.58

Aliphatic Index 16.67

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 268.83

LogP -2.83

H-bond Donors 8.0

H-bond Acceptors 10.0

Rotatable Bonds 14.0

Heavy Atoms 47.0

Ring Count 4.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0065951 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/