Peptide Database

Peptide Name8(derived from HCV C5A)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Antiviral ▸ Virucidal activity

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC51H71N13O14

DescriptionStandard

        SWLRDIWD
    

Molecular Weight1090.19 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-1.53

Net Charge (pH 7.4) -1.74

Charge Density (pH 7.0) -0.1918

GRAVY Index-0.72

Hydrophobic Moment 0.77

Boman Index-0.06

Instability Index48.25

Aliphatic Index 97.50

Aromaticity 0.2500

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 455.33

LogP -1.46

H-bond Donors 17.0

H-bond Acceptors 13.0

Rotatable Bonds 32.0

Heavy Atoms 78.0

Ring Count 4.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0365453 VERIFIED: YES

Provenance & Taxonomy

OrganismHepatitis C virus [Virus]

FamilyVirus-derived peptide

Tax ID3052230;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Virucidal

TargetHepatitis C virus (Viral membrane); Huh-7 cells

Activity27 μM

MethodRT-PCR

PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/

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