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MYP_037601
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Basic Information
Bacteriocin sublancin-168
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
37 amino acids
C156H248N50O46S5
Standard
Sequence
GLGKAQCAALWLQCASGGTIGCGGGAVACQNYRQFCR
Physicochemical Analysis
3720.27 Da
8.80
2.71
2.43
0.0732
0.24
0.64
0.16
35.76
66.22
0.0811
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1552.67
-20.61
59.0
54.0
121.0
257.0
4.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0209994 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis 168 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus cereus T
100 μg/mL
MIC
PMID9722542;28906115 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9722542/
RECORD: Rec_0288620 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis 168 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
15 μM
MIC
PMID9722542;28906115 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9722542/
RECORD: Rec_0294673 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Initially thought an unusual lantibiotic. It is actually a S-linked glyco-peptide (Oman TJ et al. 2011 Nat Chem Biol 7:78-80), i.e. a class IV bacteriocin according to the original classification. Sublancin does not react with iodoacetamide demonstrating it does not contain free thiols. However, after treatment with TCEP, four out of five cysteines became accessible for alkylation. Cys-22 glycosylation (glucose attachment) is essential for antimicrobial activity. Chemical modification: There are two disulfide bonds (C7-C36 and C14-C29). Such bridges confer superior stability to this peptide (no degradation after storing in water at room temp for TWO years!) (see the ref)
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
PaperIdentification and characterization of the structural and transporter genes for, and the chemical and biological properties of, sublancin 168, a novel lantibiotic produced by Bacillus subtilis 168
RECORD: Rec_0341548 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis 168 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus megaterium
5 μg/mL
MIC
PMID9722542;28906115 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9722542/
RECORD: Rec_0357973 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
S-linked glycopeptide
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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