Peptide Database

Peptide NameInsulin B chain

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC142H211N41O44S3

DescriptionStandard

        YSSQHLCGSNLVEALYMTCGRSGFYRPHD
    

Molecular Weight3292.64 Da

Isoelectric Point (pI)6.91

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.42

Charge Density (pH 7.0) -0.0028

GRAVY Index-0.44

Hydrophobic Moment 0.38

Boman Index-0.01

Instability Index64.30

Aliphatic Index 53.79

Aromaticity 0.1379

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1373.11

LogP -15.82

H-bond Donors 51.0

H-bond Acceptors 49.0

Rotatable Bonds 103.0

Heavy Atoms 230.0

Ring Count 7.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0021044 VERIFIED: YES

Provenance & Taxonomy

OrganismOctodon degus [Animal]

FamilyInsulin

Tax ID10160

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min

RECORD: Rec_0151992 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0228172 VERIFIED: NO

Provenance & Taxonomy

OrganismOctodon degus [Animal]

FamilyInsulin

Tax ID10160

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic