Peptide Database

Peptide NameDermaseptin-SP4 (DRS-SP4)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length75 amino acids

Chemical FormulaC363H587N99O120S4

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSMCEEEKRENEVEEEQEDDEQSELRRSLWSSIKDMAAAAGRAALNAVNGILNPGEQ
    

Molecular Weight8386.40 Da

Isoelectric Point (pI)4.45

Net Charge (pH 7.0)-7.48

Net Charge (pH 7.4) -7.73

Charge Density (pH 7.0) -0.0997

GRAVY Index-0.29

Hydrophobic Moment 0.63

Boman Index-0.03

Instability Index73.73

Aliphatic Index 93.73

Aromaticity 0.0533

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3578.14

LogP -35.06

H-bond Donors 122.0

H-bond Acceptors 117.0

Rotatable Bonds 294.0

Heavy Atoms 586.0

Ring Count 6.0

Amide Bonds 81.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0216361 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetKlebsiella pneumoniae

RECORD: Rec_0217801 VERIFIED: NO

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0303414 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0304925 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetCandida albicans

RECORD: Rec_0377983 VERIFIED: YES

Provenance & Taxonomy

OrganismAgalychnis spurrelli [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli