Peptide Database

Peptide NamePotassium channel toxin kappa-KTx 2.9

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC128H193N37O43S6

DescriptionStandard

        VDACYEACMHHHMNSDDCIEACKNPVPP
    

Molecular Weight3130.51 Da

Isoelectric Point (pI)4.77

Net Charge (pH 7.0)-4.04

Net Charge (pH 7.4) -4.47

Charge Density (pH 7.0) -0.1442

GRAVY Index-0.46

Hydrophobic Moment 0.44

Boman Index-0.01

Instability Index116.06

Aliphatic Index 45.36

Aromaticity 0.0357

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1247.85

LogP -13.48

H-bond Donors 43.0

H-bond Acceptors 48.0

Rotatable Bonds 95.0

Heavy Atoms 214.0

Ring Count 7.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0383422 VERIFIED: NO

Provenance & Taxonomy

OrganismPandinus imperator [Animal]

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-22; 8-18

Bio-Activity Profile

Function

Toxin Channel blocker

TargetKv1.2/KCNA2, Kv1.3/KCNA3