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MYP_037460
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Basic Information
Maculatin-1.1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C103H160N26O24
Standard
Sequence
GLFGVLAKVAAHVVPAIAEHF
Physicochemical Analysis
2146.53 Da
6.92
-0.06
-0.37
-0.0030
1.30
0.45
0.54
11.25
134.76
0.0952
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
757.21
-2.86
25.0
26.0
65.0
153.0
5.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0412022 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Maculatin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
2.8 μM
MIC
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0418867 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Litoria genimaculate [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
A: 24%; V: 19%. GRAVY: 1.3. Chemical modification: C-terminal NH2; d-Maculatin 1.1: the same sequence made of D-amino acids (except G) showed essentially the same activity as the WT made of L-amino acids (D=L), indicating membrane targeting. Maculatin 1.1 acid: This peptide made without C-terminal amidation lost activity against most of the bacteria with MIC > 100 ug/ml except for L. lactic (MIC 50 ug/ml). Updated 12/2010; 4/2019; 7/2020; 7/2021; 12/2024
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
Staphylococcus aureus
6-12 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1
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