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MYP_037460
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Basic Information
Maculatin-1.1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C103H160N26O24
Standard
Sequence
GLFGVLAKVAAHVVPAIAEHF
Physicochemical Analysis
2146.53 Da
6.92
-0.06
-0.37
-0.0030
1.30
0.45
0.54
11.25
134.76
0.0952
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
757.21
-2.86
25.0
26.0
65.0
153.0
5.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0359047 VERIFIED: YES
Provenance & Taxonomy
Litoria raniformis [Animal]
Maculatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
110 μM
MIC
PMID28478484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28478484/
RECORD: Rec_0369292 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
Streptococcus uberis
3 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID16140737;9620615;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
RECORD: Rec_0397833 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
Bacillus cereus
25 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID16140737;9620615;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
RECORD: Rec_0403236 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Rabbit erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/15298176/ PMID15298176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15298176/
RECORD: Rec_0404035 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
Staphylococcus aureus
6 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID16140737;9620615;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
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