Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length254 amino acids

Chemical FormulaC1292H2002N326O344S9

DescriptionStandard

        MPILHLRPQRLTTKIDQVAGINYSLVAPLTAMADCLDGQLKGEFYNVAQPSPAPFGPPALAFPPDHERMVYLGFSDYFFNTAGLVYQQAGVLHLTVTDDMIPKGSKFRLTTTFLGALIPQVAKMFPNMTVQLNIWASSPPHLTMLPTGLVFTPALETQAFAVLPNSSLAPLFVLHLVSCSQAWVNGDLSFLLPSHRLLLELKHSDVGPFSVSLRPLVRLQKGFPLPLPANVQLFNLVLQSHQNFLLLGADVHYS
    

Molecular Weight27894.28 Da

Isoelectric Point (pI)7.13

Net Charge (pH 7.0)0.27

Net Charge (pH 7.4) -0.46

Charge Density (pH 7.0) 0.0011

GRAVY Index0.30

Hydrophobic Moment 0.74

Boman Index0.23

Instability Index44.73

Aliphatic Index 105.94

Aromaticity 0.0984

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 20065.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0135222 VERIFIED: NO

Provenance & Taxonomy

OrganismUrsus maritimus [Animal]

FamilyBPI

Tax ID29073

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence