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MYP_037353
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Basic Information
Unnamed
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitor Of Endothelin-1 Release
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
7 amino acids
C37H64N12O8S
Standard
Sequence
ALPMHIR
Physicochemical Analysis
837.04 Da
9.80
0.88
0.64
0.1261
0.39
0.47
0.13
169.91
125.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
319.71
-1.09
11.0
11.0
25.0
58.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0281828 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory
PaperJacquot A., Gauthier S., Drouin R., Boutin Y.. Proliferative effects of synthetic peptides from beta-lactoglobulin and alpha-lactalbumin on murine splenocytes. Int. Dairy J., 20, 514-521, 2010.
RECORD: Rec_0318592 VERIFIED: NO
Provenance & Taxonomy
Capra hircus [Animal]
99250
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2 main protease
PaperInvestigation of beta-lactoglobulin-derived bioactive peptides against SARS-CoV-2 (COVID-19): in silico analysis. European Journal of Pharmacology 891:173781 (2021). PMID: 33271151. PMID33271151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33271151/
RECORD: Rec_0344842 VERIFIED: NO
Provenance & Taxonomy
Salvia hispanica [Plant]
ACE-inhibitory peptide
4116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
43 μM
IC50
PaperWhey Proteins as Source of Bioactive Peptides Against Hypertension
RECORD: Rec_0353061 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactokinin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Endothelial cells
PaperInfluence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1 by endothelial cells | Maes, W. et al. | DOI: 10.1016/j.regpep.2003.11.005 Evidence URLhttps://www.uniprot.org/uniprotkb/P02754/entry
RECORD: Rec_0387149 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Lactoglobulin-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cell-proliferative Growth-promoting Lymphocyte-proliferative Immunomodulatory
Murine splenocytes
Cell proliferation assay
PaperProliferative effects of synthetic peptides from β-lactoglobulin and α-Lactalbumin on murine splenocytes | Jacquot, A. et al. | DOI: 10.1016/j.idairyj.2010.02.013 Evidence URLhttps://www.uniprot.org/uniprotkb/P02754/entry
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