Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2596H4033N647O743S17

DescriptionStandard

        MMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGMEMIEQMVKERNIQDLKGSESPEFLKIYYVNYHFINIKINAFALPNTSLAFVPGVGIRALINHGTANISTDWEIKSPLFQDTGGADLFLSGVYFTGIVVLAQDDFGHPILKLQDCYAQVSHNDISFSGELSVLYNSFAEPMEKPILKNLNKMLCPIITSEVEAVNANLSRLEVLRKIDNYTLLDYSLISSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHNDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTEEIFSHLIRNSQGLGNMLSRIAELYILSQPFMVQVLATQPPVVNLLPGNFTLDIPASFVILTQSKNSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFHLSLPESSRSNVEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVLEGFLLISTDLKYKTSLKQQPSFHGWEVLNLISGQWRGKPAP
    

Molecular Weight56739.78 Da

Isoelectric Point (pI)5.44

Net Charge (pH 7.0)-10.62

Net Charge (pH 7.4) -11.53

Charge Density (pH 7.0) -0.0209

GRAVY Index0.16

Hydrophobic Moment 0.69

Boman Index0.18

Instability Index43.61

Aliphatic Index 105.55

Aromaticity 0.1063

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56060.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0035426 VERIFIED: NO

Provenance & Taxonomy

OrganismPhyseter macrocephalus [Animal]

FamilyBPI

Tax ID9755

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence