Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2318H3704N632O668S25

DescriptionStandard

        MARGPCNAPRWASLLVLVVMSTAVAAAINPGVVVRISQKGLDYAAQQGTAVLQKELERIKIPDYSGSFKIKHLGKGHYSFYSMDIREFQLPSSQIRMVPNVGLKFSISNANIKISGQWKARKSFLKTSGRFDLSIEGMSISADLKLGSNLTSGKPTVTCSSCSSHISSVHVHISNSKVGWLIRLFHKKIESALQNKLNSQVCQEVTSSVSSKLQPYLQTLPVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYRLNHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLTDDMIPKESKFRLTTKFFGSFLPEVAKMFPNMKIQIHISASAPPQLSIQPTGLSFFPALDIQAFAVLANSSLASLFLIGMSTHGSLEVGVRSDRLVGELKVDRLLLELKHSNIGPFPRSCRKASLSRCPPGSSSTTWCFSLTRTSCCLVQMLSTNEGTRGAGAVSRTCS
    

Molecular Weight51915.66 Da

Isoelectric Point (pI)9.59

Net Charge (pH 7.0)20.47

Net Charge (pH 7.4) 19.41

Charge Density (pH 7.0) 0.0430

GRAVY Index0.01

Hydrophobic Moment 0.68

Boman Index0.09

Instability Index41.79

Aliphatic Index 88.70

Aromaticity 0.0777

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37525.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0204625 VERIFIED: NO

Provenance & Taxonomy

OrganismCallithrix jacchus [Animal]

FamilyBPI/LBP

Tax ID9483

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence