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MYP_037207
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Basic Information
Japonicin-1CDYa (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C82H129N17O15S2
Standard
Sequence
FFPLALLCKVFKKC
Physicochemical Analysis
1657.14 Da
9.39
2.74
2.50
0.1955
1.25
0.53
0.33
6.24
111.43
0.2143
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
510.89
1.00
19.0
20.0
53.0
116.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0248374 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Japonicin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
8-14
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
300.0 μM
HC50
PaperLi-Li Jin et al. / Comparative Biochemistry and Physiology, Part B 154 (2009) 174-178. Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
RECORD: Rec_0267005 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
300 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/19539775/ PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
RECORD: Rec_0326350 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
Hemolysis
PMID19179051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19179051/
RECORD: Rec_0334802 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
79015
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-14
Bio-Activity Profile
Antimicrobial
Escherichia coli
25 μM
MIC
PaperIdentification and characterisation of a novel antimicrobial polypeptide from the skin secretion of a Chinese frog (Rana chensinensis).
RECORD: Rec_0389049 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
8-14
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
25 μM
MIC
PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
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