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MYP_037207
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Basic Information
Japonicin-1CDYa (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C82H129N17O15S2
Standard
Sequence
FFPLALLCKVFKKC
Physicochemical Analysis
1657.14 Da
9.39
2.74
2.50
0.1955
1.25
0.53
0.33
6.24
111.43
0.2143
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
510.89
1.00
19.0
20.0
53.0
116.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007611 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
8-14
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
100 μM
MIC
PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
RECORD: Rec_0014942 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Japonicin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
8-14
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
100.0 μM
MIC
PaperLi-Li Jin et al. / Comparative Biochemistry and Physiology, Part B 154 (2009) 174-178. Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
RECORD: Rec_0066248 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0089297 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Toxic Hemolytic Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0105968 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Japonicin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
8-14
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
25.0 μM
MIC
PaperLi-Li Jin et al. / Comparative Biochemistry and Physiology, Part B 154 (2009) 174-178. Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii PMID19539775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19539775/
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