Peptide Database

Peptide NameCruzioseptin-2 (CZS-2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length71 amino acids

Chemical FormulaC356H573N93O115S2

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEEKREEENEEVQEDDDQSEEKRGFLDVIKHVGKAALGVVTHLINQGEQ
    

Molecular Weight8060.04 Da

Isoelectric Point (pI)4.58

Net Charge (pH 7.0)-8.30

Net Charge (pH 7.4) -8.67

Charge Density (pH 7.0) -0.1169

GRAVY Index-0.28

Hydrophobic Moment 0.75

Boman Index-0.01

Instability Index56.07

Aliphatic Index 104.23

Aromaticity 0.0563

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3394.09

LogP -28.93

H-bond Donors 114.0

H-bond Acceptors 111.0

Rotatable Bonds 287.0

Heavy Atoms 566.0

Ring Count 6.0

Amide Bonds 76.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0015584 VERIFIED: YES

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyFrog skin active peptide (FSAP); Cruzioseptin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetCandida albicans

RECORD: Rec_0090299 VERIFIED: NO

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0309422 VERIFIED: YES

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyFrog skin active peptide (FSAP); Cruzioseptin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0371745 VERIFIED: YES

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyFrog skin active peptide (FSAP); Cruzioseptin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)