Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2315H3631N615O634S7

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQAIKFLEQELGQLKLQDISGDFRVLRVGKVRYEISRLYLRSFHLPHSSISLVPRVGLQVSISNAFAELDGNWRVKIYFLRDHGSFELKVENVYIKISLQLGRDALGKPTIDTSACSTHISKVHVHFSGKLGWLYNLFHAAVESRFRKLLEKQVCESVAKSVRGELQPYLRTLPVTAKLDAMTGIDYSLVAPPAATAQSLDVDLKGEFFSLAHRSAVPFSPLPVALPPDHSHMVYFGASSYFFNTAAFAYHAAGALVFNITDAVIPKAVEFRLNTTTFSAFVPQLEEMYPNAAMKFMLSAPSAPFLSIGPQGLSFQPVVDVQAYAILPGSSPAPLFLLSLVSNVSAVIDVRSGHLVGSLKVGRIKFTLKQTNVGTFQVRQLQSLVNTIASSILLPRLNERLDQGFPLPLPERIQLSKILLSFHQNFLLLGADVRYQPR
    

Molecular Weight50446.79 Da

Isoelectric Point (pI)9.52

Net Charge (pH 7.0)11.63

Net Charge (pH 7.4) 10.61

Charge Density (pH 7.0) 0.0255

GRAVY Index0.15

Hydrophobic Moment 0.71

Boman Index0.13

Instability Index36.74

Aliphatic Index 104.12

Aromaticity 0.1009

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0347904 VERIFIED: NO

Provenance & Taxonomy

OrganismEubucco bourcierii [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria