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MYP_037013
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Basic Information
Palicourein (Cyclotides; Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
37 amino acids
C159H256N48O56S6
Standard
Sequence
GDPTFCGETCRVIPVCTYSAALGCTCDDRSDGLCKRN
Physicochemical Analysis
3928.41 Da
4.78
-1.29
-1.59
-0.0350
-0.19
0.44
-0.07
60.26
52.70
0.0541
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1676.26
-23.29
65.0
61.0
124.0
269.0
4.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0227307 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
1-19; 5-21; 11-28
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
human T-lymphoblastoid cell line (CEM-SS)
0.1 μM
EC50
PaperPubMed PMID: 11430013 | PubMed PMID: 14725768 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID11430013;14725768;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11430013/
RECORD: Rec_0237319 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Plant]
Cyclotide
272141
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
1-19, 5-21, 11-28
Disulfide bonds between Cys1 and Cys19; Cys5 and Cys21; Cys11 and Cys28;hydrogen bonds between the oxygen atoms of the Glu3 carboxyl group and the backbone amides of residues Thr12, Thr13, and Ser14, and the side chain of Ser14.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.1 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0255686 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
1-19; 5-21; 11-28
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 11430013 | PubMed PMID: 14725768 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID11430013;14725768;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11430013/
RECORD: Rec_0267425 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 8.1%, E 10.8%, T 29.7%, C 51.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0272900 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antiviral Toxicity
1.5 μM
TC50
PaperA novel anti-HIV macrocyclic peptide from Palicourea condensata.
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