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MYP_037013
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Basic Information
Palicourein (Cyclotides; Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
37 amino acids
C159H256N48O56S6
Standard
Sequence
GDPTFCGETCRVIPVCTYSAALGCTCDDRSDGLCKRN
Physicochemical Analysis
3928.41 Da
4.78
-1.29
-1.59
-0.0350
-0.19
0.44
-0.07
60.26
52.70
0.0541
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1676.26
-23.29
65.0
61.0
124.0
269.0
4.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018231 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
1-19; 5-21; 11-28
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
CEM-SS cells
1.5 μM
IC50
PaperPubMed PMID: 11430013 | PubMed PMID: 14725768 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID11430013;14725768;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11430013/
RECORD: Rec_0046917 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1RF
0.1 μM
EC50
PMID11430013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11430013/
RECORD: Rec_0084826 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
1-19; 5-21; 11-28
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 11430013 | PubMed PMID: 14725768 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID11430013;14725768;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11430013/
RECORD: Rec_0200073 VERIFIED: YES
Provenance & Taxonomy
Palicourea lasiantha [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0219483 VERIFIED: YES
Provenance & Taxonomy
Palicourea condensata [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1RF
1.5 μM
IC50
PMID11430013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11430013/
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