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MYP_036992
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Basic Information
Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)]
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
94 amino acids
C418H704N134O140S7
Standard
Sequence
MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLSGVCEISGRLYRLCCR
Physicochemical Analysis
10071.33 Da
8.30
1.46
1.14
0.0155
-0.13
0.71
-0.07
35.19
87.45
0.0319
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4502.29
-59.72
168.0
149.0
345.0
699.0
3.0
102.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026466 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID1429669;16421571;15489334;12021776;9588893;12660734;15616305;22359618;25354318;30808760;17088326;19589339;23163963;22573326;25782105;29858013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1429669/
RECORD: Rec_0089306 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
L. acidophilus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID1429669;16421571;15489334;12021776;9588893;12660734;15616305;22359618;25354318;30808760;17088326;19589339;23163963;22573326;25782105;29858013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1429669/
RECORD: Rec_0122751 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
E. faecium (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID1429669;16421571;15489334;12021776;9588893;12660734;15616305;22359618;25354318;30808760;17088326;19589339;23163963;22573326;25782105;29858013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1429669/
RECORD: Rec_0143658 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
B. cereus (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID1429669;16421571;15489334;12021776;9588893;12660734;15616305;22359618;25354318;30808760;17088326;19589339;23163963;22573326;25782105;29858013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1429669/
RECORD: Rec_0147775 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Alpha-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Listeria monocytogenes (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID1429669;16421571;15489334;12021776;9588893;12660734;15616305;22359618;25354318;30808760;17088326;19589339;23163963;22573326;25782105;29858013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1429669/
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