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MYP_036946
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Basic Information
Insulin-like growth factor I
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Tissue repair / Regeneration ▸ Bone regeneration
Standard
70 amino acids
C331H518N94O101S7
Standard
Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Physicochemical Analysis
7654.68 Da
7.76
0.71
0.40
0.0101
-0.27
0.46
-0.05
67.24
60.00
0.1000
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3126.93
-34.81
115.0
109.0
246.0
533.0
12.0
72.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0335776 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Insulin
9796
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID3941093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3941093/
RECORD: Rec_0337279 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
IGF
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
S-CM=S-carboxymethylated
Bio-Activity Profile
Growth regulation Development regulation
Radioimmunoassay, Binding protein radioactivity assay and IGF-region radioactivity
Eight merino lambs plasma, in vivo; 3060 s
PMID3379352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3379352/
RECORD: Rec_0342573 VERIFIED: YES
Provenance & Taxonomy
Ailuropoda melanoleuca [Animal]
Insulin
9646
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID632300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/632300/
RECORD: Rec_0369506 VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Insulin-like growth factor
9615
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
bone-derived osteoblastic (PyMS) cells
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin-like growth factor I (Canis lupus familiaris): PMID 8359700##11145579 PMID8359700;11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8359700/
RECORD: Rec_0377235 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
IGF
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Labelled with 125I, Disulphide bond is reduced
Bio-Activity Profile
Growth regulation Development regulation
Radioimmunoassay, Binding protein radioactivity assay and IGF-region radioactivity
Eight merino lambs plasma, in vivo; 21600 s
PMID3379352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3379352/
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