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MYP_036946
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Basic Information
Insulin-like growth factor I
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Tissue repair / Regeneration ▸ Bone regeneration
Standard
70 amino acids
C331H518N94O101S7
Standard
Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Physicochemical Analysis
7654.68 Da
7.76
0.71
0.40
0.0101
-0.27
0.46
-0.05
67.24
60.00
0.1000
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3126.93
-34.81
115.0
109.0
246.0
533.0
12.0
72.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0309191 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone replacement
CHO
Half life ranges from 10 to 16 hours with a mean of 13 hours[F4054]. Mecasermin rinfabate is said to have a longer half life than [DB01277][A176065].
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1614
RECORD: Rec_0319290 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Insulin-like growth factor
10141
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperBinding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
RECORD: Rec_0322683 VERIFIED: YES
Provenance & Taxonomy
Ailuropoda melanoleuca [Animal]
Insulin-like growth factor
9646
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperBinding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
RECORD: Rec_0330610 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Insulin-like growth factor
9796
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
bone-derived osteoblastic (PyMS) cells
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin-like growth factor I (Equus caballus): PMID 8860303##11145579 PMID8860303;11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8860303/
RECORD: Rec_0335556 VERIFIED: YES
Provenance & Taxonomy
Ailuropoda melanoleuca [Animal]
Insulin-like growth factor
9646
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperBinding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
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