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MYP_036946
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Basic Information
Insulin-like growth factor I
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Tissue repair / Regeneration ▸ Bone regeneration
Standard
70 amino acids
C331H518N94O101S7
Standard
Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Physicochemical Analysis
7654.68 Da
7.76
0.71
0.40
0.0101
-0.27
0.46
-0.05
67.24
60.00
0.1000
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3126.93
-34.81
115.0
109.0
246.0
533.0
12.0
72.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0290640 VERIFIED: YES
Provenance & Taxonomy
Panthera tigris altaica [Animal]
Insulin
74533
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID3390164 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3390164/
RECORD: Rec_0299242 VERIFIED: YES
Provenance & Taxonomy
Ailurus fulgens [Animal]
Insulin-like growth factor
9649
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperBinding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
RECORD: Rec_0303196 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Insulin-like growth factor
9823
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperBinding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
RECORD: Rec_0306644 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Escherichia coli [Bacterium]
IGF-1
9606;562
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Growth factor IGF-1 replacement
3 h
PaperPubMed-linked source references: PMID:19627167; PMID:19198769 PMID19627167;19198769 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19627167/ PatentUS5200509
RECORD: Rec_0309191 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone replacement
CHO
Half life ranges from 10 to 16 hours with a mean of 13 hours[F4054]. Mecasermin rinfabate is said to have a longer half life than [DB01277][A176065].
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1614
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