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MYP_036946
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Basic Information
Insulin-like growth factor I
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Tissue repair / Regeneration ▸ Bone regeneration
Standard
70 amino acids
C331H518N94O101S7
Standard
Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Physicochemical Analysis
7654.68 Da
7.76
0.71
0.40
0.0101
-0.27
0.46
-0.05
67.24
60.00
0.1000
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3126.93
-34.81
115.0
109.0
246.0
533.0
12.0
72.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0166110 VERIFIED: YES
Provenance & Taxonomy
Ailurus fulgens [Animal]
Insulin-like growth factor
9649
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperBinding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
RECORD: Rec_0171581 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin-like growth factor
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin-like growth factor I (Homo sapiens): PMID 632300##11145579 PMID632300;11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/632300/
RECORD: Rec_0184514 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
IGF
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Growth regulation Development regulation
Radioimmunoassay
(Dose i/v injected)Chicken plasma, in vivo; <900 s
PMID3108068 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3108068/
RECORD: Rec_0194613 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin-like growth factor
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin-like growth factor I (Homo sapiens): PMID 632300##11145579 PMID632300;11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/632300/
RECORD: Rec_0195256 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
insulin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Cytokine Growth factor Insulin family Growth factor signaling Hormone Integrin-binding
PaperPDB 1GZY structural record; X-ray; 2.54 A; chain B; residues 1-70
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