MYP_036946
Insulin-like growth factor I
Binding / Molecular interaction
▸
Binding activity
Hormonal / Endocrine
▸
Hormone peptide
Immunology
▸
Immune modulation
▸
Cytokine modulation
Neurological / Signaling
▸
Neuromodulation
Neurological / Signaling
▸
Neuropeptide activity
▸
Neuropeptide
Regulatory peptide
▸
Biological modulation
Regulatory peptide
▸
Biological regulation
Regulatory peptide
▸
Cell signaling / Growth factor signaling
▸
Growth factor activity
Therapeutic / Biomedical activity
▸
Regenerative medicine
▸
Tissue repair / Regeneration
▸
Bone regeneration
Standard
70 amino acids
C331H518N94O101S7
Standard
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
7654.68 Da
7.76
0.71
0.40
0.0101
-0.27
0.46
-0.05
67.24
60.00
0.1000
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
3126.93
-34.81
115.0
109.0
246.0
533.0
12.0
72.0
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0092934
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Escherichia coli [Bacterium]
Insulin
9606;562
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Inter-chain and intra-chain disulfide architecture described for insulin therapeutic
Bio-Activity Profile
Hormone replacement
CHO
5.8 hours
RECORD: Rec_0112876
VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Insulin-like growth factor
9823
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone
Endocrine
Neuropeptide
Neuromodulator
Metabolic regulation
Physiological regulation
Growth regulation
Development regulation
Receptor modulation
bone-derived osteoblastic (PyMS) cells
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
RECORD: Rec_0114151
VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Insulin-like growth factor
9913
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone
Endocrine
Neuropeptide
Neuromodulator
Metabolic regulation
Physiological regulation
Growth regulation
Development regulation
Receptor modulation
integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
RECORD: Rec_0124966
VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
insulin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Cytokine
Growth factor
Insulin family
RECORD: Rec_0144260
VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
IGF
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Labelled with 125I
Bio-Activity Profile
Growth regulation
Development regulation
Radioimmunoassay, Binding protein radioactivity assay and IGF-region radioactivity
Eight merino lambs plasma, in vivo; 23400 s
Showing 5 records on this page · Page 4 of 11