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MYP_036946
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Basic Information
Insulin-like growth factor I
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Tissue repair / Regeneration ▸ Bone regeneration
Standard
70 amino acids
C331H518N94O101S7
Standard
Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Physicochemical Analysis
7654.68 Da
7.76
0.71
0.40
0.0101
-0.27
0.46
-0.05
67.24
60.00
0.1000
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3126.93
-34.81
115.0
109.0
246.0
533.0
12.0
72.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0068574 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Insulin
10141
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID632300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/632300/
RECORD: Rec_0072595 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID632300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/632300/
RECORD: Rec_0073955 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
IGF
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
I125 radiolabeling
Bio-Activity Profile
Growth regulation Cell proliferation regulation
5 days. Proteoglycan synthesis(matrix) synthesis is increased ~ 3 times in E3A/F49A treated sampleas compare to control as measured by scientillation counter
0.04 μg/mL
TCA precipitation
Intravenous injection into rat, in vivo; 21168 s
PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
RECORD: Rec_0081913 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0091923 VERIFIED: YES
Provenance & Taxonomy
Ailurus fulgens [Animal]
Insulin
9649
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID632300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/632300/
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